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目的:观察清热化湿中药方剂辅助治疗阴道炎的疗效。方法:回顾性分析1200例阴道炎湿热下注证患者的临床资料,按照随机数字表法分为2组各600例,对照组采用硝呋太尔制霉素阴道软胶囊治疗,治疗组在对照组治疗基础上加用清热化湿中药方剂治疗。检测2组患者治疗前后阴道冲洗液p H值、分泌型免疫球蛋白A(s Ig A)、乳酸脱氢酶(LDH)及白细胞介素-1β(IL-1β);统计2组治疗前后中医证候积分、临床疗效、不良反应发生情况;随访6月,统计2组治愈患者的复发人数。结果:治疗后,2组s Ig A、p H值、LDH及IL-1β水平较治疗前升高或下降,治疗组升高或下降程度较对照组显著,差异均有统计学意义(P<0.05)。治疗后,2组中医证候积分均较治疗前下降,治疗组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗组总有效率高于对照组,复发率低于对照组,差异均有统计学意义(P<0.01)。结论:应用清热化湿中药方剂辅助治疗阴道炎疗效显著且较安全。
Objective: To observe the curative effect of Qingre Huashi Compound Prescription for the treatment of vaginitis. Methods: A retrospective analysis of 1,200 cases of vaginitis in patients with clinical evidence of damp-heat injection, according to the random number table divided into two groups of 600 cases, the control group nifuratel neomycin vaginal soft capsule treatment group in the control Group therapy based on the use of heat dampness herbal prescription treatment. The levels of p H, s Ig A, LDH and IL-1β in vaginal wash fluid of two groups before and after treatment were measured. Syndrome score, clinical efficacy, adverse reactions; follow-up in June, the number of patients in two groups cured recurrence statistics. Results: After treatment, the levels of s Ig A, p H, LDH and IL-1β in the two groups increased or decreased compared with those before treatment, and the levels of s Ig A and p-ER in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, the scores of TCM syndromes in both groups decreased compared with before treatment, and the scores of TCM syndromes in the treatment group were lower than those in the control group (P <0.05). The total effective rate of the treatment group was higher than that of the control group, the recurrence rate was lower than that of the control group, the differences were statistically significant (P <0.01). Conclusion: The application of Qingre Hua wet traditional Chinese medicine prescription adjuvant treatment of vaginitis significant and safe.