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目的观察阿司匹林与氯吡格雷双联负荷量短期治疗短暂性脑缺血发作(TIA)的近期疗效。方法选取2013年6月至2014年6月86例TIA患者为研究对象,将患者随机分为观察组与对照组,每组43例。两组均给予基础治疗,观察组行阿司匹林与氯吡格雷双联负荷量干预,对照组行阿司匹林单一负荷量干预,采用国立卒中研究量表(NIHSS)比较两组临床疗效,检测两组治疗前,治疗14 d、30 d后C-反应蛋白(CRP)水平,并记录不良反应发生率。结果观察组有效率(90.70%)高于对照组(72.09%),差异有统计学意义(P<0.05)。两组CRP水平治疗前比较差异未见统计学意义(P>0.05);观察组治疗14 d、30 d后CRP水平[(5.36±1.82)mg/L、(4.25±1.86)mg/L]低于对照组[(8.63±1.62)mg/L、(7.63±1.91)mg/L],差异有统计学意义(P<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论阿司匹林与氯吡格雷双联负荷量短期治疗TIA可有效改善患者炎症反应,提高临床治疗效果且不良反应并未显著增加,安全可靠,值得在临床推广使用。
Objective To observe the short-term effect of aspirin and clopidogrel combined with short-term treatment of transient ischemic attack (TIA). Methods From June 2013 to June 2014, 86 TIA patients were selected as study subjects, and the patients were randomly divided into observation group and control group, with 43 cases in each group. The two groups were given basic treatment. The observation group was treated with aspirin and clopidogrel in combination with double load. The control group was given aspirin single load intervention. The National Stroke Scale (NIHSS) was used to compare the clinical curative effect between the two groups. , C-reactive protein (CRP) level after treatment for 14 and 30 days, and the incidence of adverse reactions were recorded. Results The observation group (90.70%) was higher than the control group (72.09%), the difference was statistically significant (P <0.05). There were no significant differences in CRP levels between the two groups before treatment (P> 0.05). The levels of CRP in the observation group after treatment for 14 d and 30 d [(5.36 ± 1.82) mg / L and (4.25 ± 1.86) mg / L] The difference was statistically significant (P <0.05) in the control group [(8.63 ± 1.62) mg / L, (7.63 ± 1.91) mg / L]. There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions Short-term treatment of TIA with aspirin and clopidogrel double-load can effectively improve the inflammatory response and improve the clinical effect without adverse reactions, which is safe and reliable. It is worth to be used clinically.