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目的探讨氯吡格雷治疗中青年脑梗死的临床疗效。方法选择2008~2012年本院中青年脑梗死患者128例,随机分为观察组及对照组各64例,两组均给予常规治疗,对照组给予口服阿司匹林肠溶片100 mg/d,观察组给予口服氯吡格雷50~75 mg/d,两组连续服用48周,在治疗的第2周、第24周分别进行神经功能缺损程度及日常生活活动能力量表(ADL)的评分,并随访两组的再发情况。结果两组在治疗第2周进行神经功能缺损程度及ADL评分比较差异无显著性(P>0.05),在第24周进行神经功能缺损程度及(Barthel指数评分)?比较差异有显著性(P<0.05)。48周内随访两组的再发情况,观察组的再发率低于对照组,差异具有显著性(P<0.05)。结论氯吡格雷治疗中青年脑梗死的临床疗效可靠,效果显著,并具有预防再发脑梗死的作用。
Objective To investigate the clinical efficacy of clopidogrel in the treatment of young and middle-aged patients with cerebral infarction. Methods 128 cases of young and middle-aged patients with cerebral infarction in our hospital from 2008 to 2012 were randomly divided into observation group and control group, 64 cases in each group. Both groups were given routine treatment. The control group was given aspirin 100 mg / d, Given oral clopidogrel 50 ~ 75 mg / d, two groups of 48 consecutive weeks of treatment in the first two weeks of treatment, respectively, the first 24 weeks of neurological deficits and activities of daily living scale (ADL) score, and follow-up The recurrence of two groups. Results There was no significant difference between the two groups in the degree of neurological deficit and the ADL score in the second week of treatment (P> 0.05). The degree of neurological deficit and the Barthel index in the 24th week were significantly different (P <0.05). After 48 weeks of follow-up, the relapse rate of the two groups was lower than that of the control group, the difference was significant (P <0.05). Conclusion Clopidogrel treatment of cerebral infarction in young and middle-aged patients with a reliable clinical effect, the effect is significant, and have the role of prevention of recurrent cerebral infarction.