论文部分内容阅读
目的探讨低氧放疗对中晚期食管癌的近远期疗效及不良反应。方法将66例欲接受根治性放疗的食管癌患者随机分为低氧组和空气组。所有患者均行三维适形放射治疗,1.8～2.0Gy/次,每周5次,总剂量为64～66Gy。低氧组在放射治疗时吸入10.5%低氧气体,空气组在放射治疗过程中吸入空气。观察两组患者的总有效率、远处转移率、远期生存率和放射治疗反应。结果低氧组和空气组有效率分别为68.9%和71.9%(2=0.0749,P=0.7844),1年生存率分别为75.0%和59.4%(2=1.7719,P=0.1832),3年生存率分别为56.3%和31.3%(2=4.0635,P=0.0438),5年生存率分别为34.4%和12.5%(2=4.2667,P=0.0389)。低氧组的放射治疗急性反应和远处转移率均低于空气组。结论低氧放疗能提高食管癌患者的远期生存率,并能减少放射治疗的不良反应。
Objective To investigate the short-term and long-term effects and adverse reactions of hypoxic radiotherapy on advanced esophageal cancer. Methods Sixty-six patients with esophageal cancer who underwent radical radiotherapy were randomly divided into hypoxia group and air group. All patients underwent three-dimensional conformal radiotherapy, 1.8 ~ 2.0Gy / time, 5 times a week, the total dose of 64 ~ 66Gy. In the hypoxia group, 10.5% hypoxia was inhaled during radiotherapy, and the air group inhaled air during radiotherapy. The total effective rate, distant metastasis rate, long-term survival rate and radiotherapy response were observed in both groups. Results The effective rates of hypoxia group and air group were 68.9% and 71.9% (2 = 0.0749, P = 0.7844, respectively), and the 1-year survival rates were 75.0% and 59.4% (2 = 1.7719, P = 0.1832) The annual survival rates were 56.3% and 31.3% respectively (2 = 4.0635, P = 0.0438). The 5-year survival rates were 34.4% and 12.5% respectively (2 = 4.2667, P = 0.0389). The acute response and distant metastasis of radiotherapy in hypoxic group were lower than those in air group. Conclusion Hypoxic radiotherapy can improve the long-term survival rate of esophageal cancer patients and reduce the adverse reactions of radiotherapy.