多发性骨髓瘤 (ＭＭ )是恶性浆细胞病中最常见的一种 ,是Ｂ淋巴细胞演变成浆细胞后无限制增生的疾病。多见于中老年人 ,近年来随着人寿命的延长和人口老龄化的加剧 ,本病的发生率正逐年上升。但病因至今未明 ,治疗仍以化疗为主 ,尚无有效的预防和根治方法。所以研究ＭＭ的病因 Multiple myeloma (MM) is one of the most common types of malignant plasma cell disease and is a disease of unprotected hyperplasia after B lymphocytes have evolved into plasma cells. More common in the elderly, with the extension of life expectancy in recent years and population aging, the incidence of this disease is increasing year by year. But the etiology is still unknown, the treatment is still based on chemotherapy, there is no effective prevention and cure. So the etiology of MM