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目的:检测不同海拔高度下肺心病患者右心室功能与血清ET-1水平变化的相关性。方法:将肺心病患者根据海拔分为高原组和平原组,采用彩色多普勒超声心动图对右心室前壁厚度、右室流出道宽度等指标进行测量比较。血清ET含量利用放射免疫技术进行测定。结果:高原组肺动脉瓣a波消失、右室前壁增厚和左右肺动脉宽度出现频率显著高于平原组(P<0.01);右室流出道增宽、室间隔增宽率高原组高于平原组(P<0.05);平均肺动脉压也高于平原组(P<0.05);高原组血清ET-1含量也显著高于平原组,并与肺动脉压存在一定的正相关。结论:高原肺心病右心病变较平原组严重,其与血清ET-1的水平变化有明显的相关性。
Objective: To detect the correlation between right ventricular function and serum ET-1 level in patients with cor pulmonale at different altitudes. Methods: The patients with pulmonary heart disease were divided into plateau group and plain group according to the altitude. Color thickness Doppler echocardiography was used to measure the thickness of right ventricular anterior wall and width of right ventricular outflow tract. Serum ET levels were measured using radioimmunoassay. Results: The a-wave of pulmonary valve disappeared in the plateau group, and the frequency of right ventricular anterior wall thickening and left and right pulmonary artery width were significantly higher than those in the plain group (P <0.01); the right ventricular outflow tract was widened and the ventricular septal broadening rate was higher in the plateau group than in the plain (P <0.05). The mean pulmonary arterial pressure was also higher in the plateau group than in the plain group (P <0.05). The ET-1 level in the plateau group was also significantly higher than that in the plain group and positively correlated with pulmonary arterial pressure. CONCLUSION: The right heart disease in severe pulmonary heart disease is more severe than in plain group, and it has obvious correlation with the level of serum ET-1.