目的：观察重度妊高征患者治疗前后内皮素（ＥＴ）及一氧化氮（ＮＯ）的变化与新生儿质量的关系。方法：分别采用放射免疫测定法及Ｇｒｅｉｓ法对４２例重度妊高征患者解痉降压治疗前后血浆ＥＴ、血清ＮＯ的稳定代谢产物亚硝酸盐（硝酸盐）ＮＯ－２（ＮＯ－３）进行测定。结果：新生儿体重＜２５００ｇ组及Ａｐｇａｒ评分≤７分的妊高征（ＰＩＨ）患者治疗前后ＥＴ及ＮＯ－２（ＮＯ－３）水平无显著差异（Ｐ＞００５）；新生儿体重≥２５００ｇ及Ａｐｇａｒ评分＞７分的ＰＩＨ孕妇治疗后ＥＴ水平低于治疗前（Ｐ＜００５），ＮＯ－２（ＮＯ－３）水平高于治疗前（Ｐ＜００５）。结论：加强围产期监测，早期发现早期治疗，是改善胎儿宫内生长发育、提高新生儿质量的关键 Objective: To observe the relationship between the changes of endothelin (ET) and nitric oxide (NO) before and after treatment and the quality of newborn infants with severe pregnancy-induced hypertension. Methods: 42 patients with severe PIH were treated with antispasmodic and antihypertensive therapy respectively by radioimmunoassay (RIA) and Greis method. Nitric oxide (NO) 2 (NO-2), a stable metabolite of plasma ET and serum NO, Determination. Results: There was no significant difference in the levels of ET and NO-2 before and after treatment (P> 005) in neonates with PIH <2500g and those with Apgar score ≤7. Neonatal weight ≥ The ET level of PIH with 2500g and Apgar score> 7 was lower than before treatment (P <005), NO-2 (NO-3) was higher than before treatment (P <005). Conclusion: To strengthen the monitoring of perinatal period, early detection of early treatment is to improve intrauterine growth and development, improve the quality of newborn key