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目的探讨HBV发生YMDD自然变异的相关因素。方法对未经任何治疗的96例检测YMDD变异的HBV感染者的临床特点进行回顾性分析。结果YMDD变异率31.58%,变异组与未变异组性别、病程、ALT、PT上无差异(P>0.05);变异组年龄小于未变异组,差异有统计学意义(P<0.01);变异组CHB患病率、HBeAg阳性率高于未变异组,差异有统计学意义(P<0.01);HBV-DNA的高水平与YMDD自然变异呈正相关。结论YMDD自然变异率较高,并具有年龄相对小,CHB易发生,HBeAg阳性者多发,HBV-DNA水平高的特点。在临床中应予重视,积极检测,以便合理制定治疗方案。
Objective To investigate the related factors of natural mutation of YMDD in HBV. Methods A retrospective analysis was performed on the clinical features of 96 untreated HBV infected patients tested for YMDD mutation. Results The mutation rate of YMDD was 31.58%. There was no significant difference in gender, course of disease, ALT and PT between the mutation group and the non-mutation group (P> 0.05), and the difference was statistically significant (P <0.01) The prevalence of CHB was higher than that of non-mutation group (P <0.01). The high level of HBV-DNA was positively correlated with the natural mutation of YMDD. Conclusion YMDD has a high rate of natural mutation and has the characteristics of relatively small age, easy occurrence of CHB, frequent HBeAg positive and high level of HBV-DNA. In the clinical should pay attention to positive testing, so that a reasonable formulation of treatment options.