,Copy number variants of ABCF1, IL17REL,and FCGR3A are associated with the risk of gout

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Dear Editor,Gout is usually characterized by recurrent flares of acute inflammatory arthritis and the crystallization of urate in tissues and joints (Dong et al.,2017).The formation of monosodium urate crystals (MSU) is due to the elevated uric acid levels in the blood (Yang et al.,2016).But only 10% of individuals with hyperuricemia develop gout,suggesting that certain people are at a higher risk of developing MSU crystals (Merriman and Dalbeth,2011) or initiating of the acute inflammatory response than others.
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