现在有关膳食对机体影响的代谢组学研究仅仅是研究膳食对血样和尿样的影响,而忽略了其他生物样本,例如盲肠内容物,就等于遗漏了消化系统的作用和忽略了肠道微生物菌群在代谢中的重要作用和其在生物利用率方面的影响。许多研究已经证明多组织样本代谢组学在评估营养物质在机体内的代谢影响方面的重要性。然而这些研究都是以核磁共振技术为分析手段的,由于核磁共振技术的低灵敏度,限制了可检测代谢产物的数量。而四级杆分行时间质谱仪具有较高 Metabolomic studies on the effects of diets on the body now only focus on the effects of diets on blood and urine samples, neglecting other biological samples such as the caecal contents equals the omission of the digestive system and neglecting the intestinal microflora The importance of the group in metabolism and its impact on bioavailability. Many studies have demonstrated the importance of multi-tissue sample metabonomics in assessing the metabolic effects of nutrients on the body. However, these studies are based on NMR techniques, which limit the amount of detectable metabolites due to the low sensitivity of NMR techniques. The quadrupole time-of-flight mass spectrometer is taller