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目的:检测低剂量米非司酮联合妈富隆对功能性子宫出血患者性激素浓度的影响,观察其治疗效果。方法:80例功能失调性子宫出血患者随机分为观察组和对照组,对照组给予小剂量米非司酮治疗,观察组在对照组基础上联用妈富隆治疗。检测两组患者雌激素(E2)、促卵泡生成素(FSH)以及黄体生成素(LH);对比观察两组患者控制出血时间和完全止血时间。结果:观察组患者治疗前后E2、FSH以及LH浓度明显下降,且差异均有统计学意义(P<0.05);而对照组患者治疗前后性激素水平无明显变化,比较差异无统计学意义(P>0.05)。观察组患者控制出血时间(19.45±5.69)h和完全止血时间(34.81±6.25)h均短于对照组患者〔(28.49±6.53)h、45.75±7.32)h〕,且比较差异有统计学意义(P<0.05)。结论:米非司酮和妈富隆治疗功血作用机制不同,疗效也不同。二者联合应用可以起到互补作用,安全有效,值得推广。
Objective: To investigate the effect of low dose mifepristone combined with Marvelon on the sex hormones in patients with functional uterine bleeding, and to observe its therapeutic effect. Methods: Eighty patients with dysfunctional uterine bleeding were randomly divided into observation group and control group. The control group was treated with low dose mifepristone. The observation group was treated with Marvelon on the basis of the control group. Estrogen (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured in two groups. The bleeding time and the complete bleeding time were compared between the two groups. Results: Before and after treatment, the concentrations of E2, FSH and LH in the observation group decreased significantly (P <0.05), while the control group had no significant changes in the levels of sex hormones before and after treatment, with no significant difference (P> 0.05). The controlled bleeding time (19.45 ± 5.69) h and complete bleeding time (34.81 ± 6.25) h in the observation group were shorter than those in the control group 〔(28.49 ± 6.53) h, 45.75 ± 7.32 h〕, and the difference was statistically significant (P <0.05). Conclusion: The mechanisms of action of mifepristone and marvelon in treating dysfunctional uterine bleeding are different, and the curative effects are also different. The combination of the two can play a complementary role, safe and effective, it is worth promoting.