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一、关于“洋地黄化”过去认为洋地黄的作用是根据“全或无法则”,即洋地黄非达到饱和量(洋地黄化)不能发挥正性收缩能作用,用以指导洋地黄的临床应用。现在的看法是洋地黄的作用与其剂量呈线性关系,即增强心肌能力,随剂量大小而定,即使在洋地黄中毒亦然。小量洋地黄心肌收缩力小量加强,随着剂量的加大,心肌收缩力愈加强。因此剂量大小主要根据个体差异和病情需要而有所不同。心衰轻者需用洋地黄剂量也较少,心衰重者需剂量亦较大,但不一定非达到饱和量不可,因而有人主张废弃“洋地黄化”这一术语。
First, on the “digitalis” Past that the role of digitalis is based on “all or can not”, that digitalis non-reaching saturation (digitalis) can not play a positive role in contractility, to guide the clinical digitalis application. The current view is that the role of digitalis and its dose was linear, that is, to enhance myocardial capacity, depending on the dose size, even in digitalis poisoning. A small amount of digitalis myocardial contractility a small amount of strengthening, with the dose increased, myocardial contractility stronger. Therefore, the size of the dose based on individual differences and the needs of the disease vary. Small amount of heart failure need to use digitalis less dose, heart failure patients need a larger dose, but not necessarily non-saturation can not, so some people advocate discard the “digitalis” terminology.