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血吸虫病肝纤维化是宿主感染血吸虫后发生免疫反应导致的严重病理损害。宿主处于何种免疫应答状态决定了肝纤维化的进展。当宿主体内以Th1免疫应答为主时,不易发生肝纤维化;而宿主体内以Th2免疫应答为主时,易形成肝纤维化。细胞因子及共刺激分子在Th1/Th2极化过程中均发挥重要的作用。本文综述了细胞因子和共刺激分子调控Th1/Th2极化的作用及其与血吸虫病肝纤维化发生、发展相关性的研究进展。
Schistosomiasis Hepatic fibrosis is a severe pathological damage caused by an immune response that occurs after the host has ingested Schistosoma japonicum. The immune response status of the host determines the progress of liver fibrosis. When the host is mainly Th1 immune response, not prone to liver fibrosis; while the host body to Th2 immune response predominant, easy to form liver fibrosis. Cytokines and costimulatory molecules play an important role in Th1 / Th2 polarization. This review summarizes the roles of cytokines and co-stimulatory molecules in the regulation of Th1 / Th2 polarization and their correlation with the occurrence and development of hepatic fibrosis in schistosomiasis.