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[目的]探讨血必净注射液对肝癌患者经导管肝动脉化疗栓塞术(TACE)后血浆内毒素及肝功能的影响。[方法]将56例肝癌患者随机分为治疗组与对照组;TACE后,2组均行常规保肝(还原性谷胱甘肽、甘草酸二胺等)治疗,疗程7 d;治疗组在此基础上加用血必净注射液疗程7 d。检测2组TACE前后肝功能和血浆内毒素水平。[结果]治疗组血浆内毒素水平和血清ALT、AST、TBil与术前相比轻度升高(P<0.05),而对照组血浆内毒素水平和血清ALT、AST、TBil与术前相比明显升高(P<0.05)。治疗组TACE后血浆内毒素水平,血清ALT、AST、TBil升高程度低于对照组,差异有统计学意义(P<0.05)。[结论]血必净注射液能降低肝癌患者TACE后血浆内毒素水平,从而减轻对肝功能的损伤。
[Objective] To investigate the effect of Xuebijing injection on plasma endotoxin and liver function after transcatheter arterial chemoembolization (TACE) in patients with liver cancer. [Methods] Fifty-six patients with liver cancer were randomly divided into treatment group and control group. After TACE, the two groups were treated with routine hepatoprotective (reducing glutathione, glycyrrhizin, etc.) for 7 days. On this basis, add Xuebijing injection for 7 days. Liver function and plasma endotoxin levels were measured before and after TACE in two groups. [Results] The levels of plasma endotoxin and serum ALT, AST and TBil in the treatment group were slightly higher than those before operation (P <0.05), while the levels of plasma endotoxin and serum ALT, AST and TBil in the control group were significantly lower than those before operation Was significantly higher (P <0.05). The level of plasma endotoxin and serum ALT, AST and TBil in TACE group after treatment were lower than those in control group (P <0.05). [Conclusion] Xuebijing Injection can reduce the plasma endotoxin level after TACE in liver cancer patients and reduce the damage of liver function.