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胸腺是Ｔ 细胞发育的重要场所，随增龄而出现的老化，特别是胸腺所表现出的明显的萎缩势必影响到Ｔ 细胞的发育，进而造成外周淋巴组织中Ｔ 细胞的质与量的异常。这就继发性影响机体对病原微生物的免疫应答水平。胸腺萎缩究竟是怎样触发和如何受控的呢？ 目前有一些假说理论和实验依据来解释其成因。本文对近年此方面的研究进展作一简要综述。
The thymus is an important site for the development of T cells. The appearance of aging along with age, especially the obvious shrinkage of the thymus, will inevitably affect the development of T cells, leading to the abnormalities of the quality and quantity of T cells in peripheral lymphoid tissues. This secondary effect on the body’s immune response to pathogenic microorganisms. How thymic atrophy triggered and how to control it? There are a number of hypothesis theories and experimental evidence to explain its causes. This article gives a brief overview of the research progress in this area in recent years.