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目的探讨血清唾液酸(SA)含量对检测早期无症状风湿性心脏病患者的临床意义。方法 55例风湿性心脏病患者分为2组,无明显症状组31例,明显症状组24例,对患者血清SA水平进行检测,对不同组之间的血清SA水平进行分析;同时检测受试者心肌酶谱,将心肌酶谱结果与血清唾液酸的结果作对照。结果风湿性心脏病患者的SA水平明显高于对照组,差异有统计学意义(P<0.05);明显症状组患者血清SA水平与无明显症状组差异无统计学意义(P>0.05);与对照组相比,风湿性心脏病患者心肌酶谱肌酸激酶(CK)水平明显升高,差异有统计学意义(P<0.05);以SA作为检测指标检出率比心肌酶谱的检出率高。结论检测风湿性心脏病患者血清SA含量对风湿性心脏病的早期检测具有临床意义。
Objective To investigate the clinical significance of serum sialic acid (SA) level in early asymptomatic patients with rheumatic heart disease. Methods Fifty-five patients with rheumatic heart disease were divided into two groups. There were 31 patients without obvious symptoms and 24 patients with obvious symptoms. Serum SA levels were measured in patients with SA and serum SA levels were analyzed. Myocardial enzymes, the results of myocardial enzymes and serum sialic acid as a control. Results The level of SA in patients with rheumatic heart disease was significantly higher than that in the control group (P <0.05). There was no significant difference in serum SA level between patients with obvious symptoms and those without symptoms (P> 0.05) Compared with the control group, the myocardial enzymes in patients with rheumatic heart disease increased creatine kinase (CK) levels significantly (P <0.05), the detection rate of SA was higher than that of myocardial enzymes High rate. Conclusion The detection of serum SA in patients with rheumatic heart disease has clinical significance for the early detection of rheumatic heart disease.