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目的探讨慢性阻塞性肺疾病(COPD)合并肺部真菌感染患者的病原菌分布特点、临床特点以及治疗方案。方法收集2012年3月至2013年3月辽宁省盘锦市中心医院呼吸内科收治的21例COPD合并肺部真菌感染患者的资料,分析患者的肺部真菌感染情况、胸部CT和血常规检查结果以及临床治疗效果。结果 21例患者中,感染白色念珠菌7例,占33.3%,热带念珠菌6例,占28.6%,酵母菌3例,占14.3%,曲霉菌2例,占9.5%,其他真菌3例,占14.3%;临床治疗的总有效率为85.7%,不良反应发生率为19.0%。结论及时诊断并制订科学有效的临床治疗方案是治疗COPD合并肺部真菌感染的关键,可以有效提高临床治疗效果,降低病死率。
Objective To investigate the distribution characteristics, clinical characteristics and treatment of pathogenic bacteria in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary fungal infection. Methods The data of 21 patients with COPD with pulmonary fungal infection admitted from Department of Respiratory Medicine, Panjin Central Hospital, Liaoning Province from March 2012 to March 2013 were collected. The pulmonary fungal infection, chest CT and blood test results were analyzed. Clinical treatment effect. Results Among the 21 patients, Candida albicans was infected in 7 cases (33.3%), Candida tropicalis (6 cases), Saccharomyces cerevisiae (28.6%), Saccharomyces cerevisiae (3.3%), Aspergillus spp. In 2 cases (9.5%) and other fungi Accounting for 14.3%; the total effective rate of clinical treatment was 85.7%, the incidence of adverse reactions was 19.0%. Conclusion The timely diagnosis and development of a scientific and effective clinical treatment plan is the key to the treatment of COPD complicated with pulmonary fungal infection, which can effectively improve the clinical effect and reduce the mortality rate.