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目的观察盖诺(NvB)加顺铂(DDP)联合放疗同步治疗局部晚期非小细胞肺癌(NSCLC)的临床疗效和不良反应。方法42例局部晚期NSCLC患者随机分为联合组(22例)和化疗组(20例)。化疗组单纯采用NP方案化疗.其中NVB 25mg/m~2,d1,8,静滴DDP 30mg/m~2,d1～d3,静滴。联合组在NP方案化疗基础上,同时进行常规放疗。结果42例患者全部完成治疗计划,联合组总有效率(81.8%)明显高于化疗组(45.0%,P<0.05):联合组的1年生存率(68.2%)明显高于化疗组(40.0%,P<0.05)。联合组不良反应稍高于化疗组(P>0.05)。结论盖诺加顺铂联合放疗同步治疗局部晚期非小细胞肺癌有较好的近期疗效,可提高生存率,毒性反应可耐受。
Objective To observe the clinical efficacy and side effects of concurrent treatment with NvB plus cisplatin (DDP) and radiotherapy in the treatment of locally advanced non-small cell lung cancer (NSCLC). Methods Forty-two patients with locally advanced NSCLC were randomly divided into combined group (n = 22) and chemotherapy group (n = 20). Chemotherapy group was treated with NP chemotherapy alone, including NVB 25mg / m ~ 2, d1,8, intravenous DDP 30mg / m ~ 2, d1 ~ d3, intravenous infusion. The combined group was treated with NP regimen and received conventional radiotherapy. Results All 42 patients completed the treatment plan. The total effective rate (81.8%) in the combined group was significantly higher than that in the chemotherapy group (45.0%, P <0.05). The 1-year survival rate was significantly higher in the combined group (68.2% %, P <0.05). Adverse reactions in the combination group were slightly higher than those in the chemotherapy group (P> 0.05). Conclusions Gynoblast plus cisplatin combined with radiotherapy in the treatment of locally advanced non-small cell lung cancer has a better short-term curative effect, which can improve the survival rate and tolerability of toxic reactions.