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目的:观察血塞通联合巴曲霉对急性脑梗死患者血清高敏C反应蛋白(hsCRF)及血浆血管性血友病因子(vWF)水平的影响。方法:82例急性脑梗死患者分为对照组(n=41)和治疗组(n=41),对照组应用血塞通注射液20 mL加入生理盐水注射液250 mL gtt,1次/d(d 1～d 4)。治疗组在对照组治疗的基础上,应用巴曲霉注射液20 mL加入生理盐水注射液250mL gtt(d 1,d 3,d 5)。观察比较两组患者治疗前、治疗后7,14 d时的神经功能缺损评分及血浆vWF水平、血清hsCRP水平的变化情况。结果:治疗组与对照组治疗71,4 d后,神经功能缺损评分均明显降低(P<0.01),与对照组比较,治疗组降低更明显(P<0.01)。治疗后7 d两组血浆vWF水平和血清hsCRP明显增加(P<0.01),对照组增加更明显(P<0.01);14 d时血浆vWF水平和血清hsCRP水平明显降低(P<0.01),治疗组下降更明显(P<0.01)。结论:血塞通联合巴曲酶治疗急性脑梗死的疗效优于单用血塞通。
Objective: To observe the effect of Xuesaitong combined with Aspergillus oryzae on serum hsCRF and vWF in patients with acute cerebral infarction. Methods: 82 patients with acute cerebral infarction were divided into control group (n = 41) and treatment group (n = 41). The control group was treated with Xuesaitong injection 20 mL and saline 250 mL gtt once a day d 1 ~ d 4). On the basis of the treatment of the control group, the treatment group was given 250 mL gtt (d 1, d 3, d 5) of physiological saline injection with 20 mL of Aspergillus Bajae injection. The changes of neurological deficit score, plasma vWF level and serum hsCRP level before and after treatment were observed and compared between the two groups. Results: After treatment for 71 and 4 days, the neurological deficit scores of the treatment group and the control group were significantly decreased (P <0.01). Compared with the control group, the treatment group decreased more obviously (P <0.01). At 7 days after treatment, the plasma vWF levels and serum hsCRP levels increased significantly in both groups (P <0.01), while those in control group increased more significantly (P <0.01). On the 14th day, plasma vWF levels and serum hsCRP levels were significantly lower (P <0.01) Group decreased more significantly (P <0.01). Conclusion: Xuesaitong combined with batroxobin is superior to Xuesaitong in the treatment of acute cerebral infarction.