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目的探讨动脉粥样硬化患者肿瘤坏死因子(TNF)的改变及氨氯地平对其影响。方法采用酶联免疫吸附法(ELISA法)测定50例动脉粥样硬化及15例健康人(对照组)血清TNF含量。结果动脉粥样硬化组血清TNF含量明显高于对照组(P<0.001),氨氯地平治疗动脉粥样硬化患者血清TNF水平与治疗前相比明显降低(P<0.001)。结论TNF在动脉粥样硬化发病中起重要作用,氨氯地平能降低动脉粥样硬化患者血清TNF水平。
Objective To investigate the changes of tumor necrosis factor (TNF) and the effect of amlodipine on it in patients with atherosclerosis. Methods 50 cases of atherosclerosis and 15 cases of healthy people (control group) serum TNF levels by enzyme-linked immunosorbent assay (ELISA). Results The level of serum TNF in atherosclerotic group was significantly higher than that in control group (P <0.001). The level of serum TNF in patients with amlodipine atherosclerosis was significantly lower than that before treatment (P <0.001). Conclusion TNF plays an important role in the pathogenesis of atherosclerosis. Amlodipine can reduce the level of serum TNF in patients with atherosclerosis.