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蛋白S是抗凝血过程中重要的辅因子。它可加速活化蛋白C灭活因子a、a。蛋白S基因缺陷可导致血栓形成的危险性明显增加。本文就蛋白S的结构和生物学功能、遗传性蛋白S缺陷症的分子发病机制、分类和诊断、与静脉血栓的关系以及治疗作一综述。
Protein S is an important cofactor in the anticoagulant process. It accelerates activated protein C inactivation factor a, a. Protein S gene defects can lead to a significant increase in the risk of thrombosis. This article reviews the structure and biological functions of protein S, the molecular pathogenesis, classification and diagnosis of hereditary protein S deficiency, the relationship with venous thrombosis and the treatment.