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目的:探讨急性有机磷中毒(AOPP)患者用阿托品和阿托品加东莨菪碱治疗对血胆碱脂酶(ChE)的影响和临床疗效。方法:100例患者入院后采用单盲法分组,用阿托品加其它综合治疗作为对照组,阿托品加东莨菪碱加其它综合治疗作为治疗组,按标准分为轻、中、重三度,分别于治疗前,治疗后12、24、48、72 h抽血测定ChE活性值,记录达到阿托品化时间。结果:ChE在中毒患者治疗前无差异,治疗后12 h有差异,24、48及72 h治疗组明显高于对照组(P<0.01)。结论:AOPP治疗中通过ChE变化观察,阿托品加东莨菪碱较单纯使用阿托品效果更好,能减少阿托品用量,缩短阿托品化时间,减轻阿托品的毒副作用,亦可减少中间综合征的发生。
Objective: To investigate the effects and clinical effects of atropine and atropine plus scopolamine on blood cholinesterase (ChE) in patients with acute organophosphate poisoning (AOPP). Methods: 100 patients were admitted to hospital by single-blind method, with atropine plus other comprehensive treatment as a control group, atropine plus scopolamine plus other comprehensive treatment as the treatment group, according to the standard is divided into mild, moderate and severe degree, respectively, before treatment After 12, 24, 48 and 72 h of treatment, the blood was collected to measure the activity of ChE, and the time of atropine treatment was recorded. Results: There was no difference in ChE before treatment, and there was difference at 12 h after treatment. The levels of ChE in treatment group were significantly higher than those in control group at 24, 48 and 72 h (P <0.01). Conclusion: AOPP treatment through the observation of changes in ChE, atropine plus scopolamine effect than a simple use of atropine, can reduce the amount of atropine, shortening the time of atropine, reduce the side effects of atropine, can reduce the incidence of intermediate syndrome.