[Objective] To observe the anti-inflammatory effects of alcohol extract of Phellodendri Chinensis Corte and explore its mechanism.[Method]ICR mice were divided into 5 groups randomly,namely the model group,dexameathone group( 0. 01 g/kg),alcohol extraction of Phellodendri Chinensis Corte groups( 9. 0,4. 5 and 3. 0 g / kg). Each drug was administrated to the mice orally once a day for 15 days. After30 min of the last administration,its anti-inflammatory effect was observed by the method of acetic acid-induced permeability accentuation. SD rats were divided into 5 groups randomly,namely the model group,dexameathone group( 0. 01 g / kg),alcohol extraction of Phellodendri Chinensis Corte groups( 9. 0,4. 5 and 3. 0 g / kg). Each drug was administrated to the rats orally once a day for 15 days. After 30 min of the last administration,the rat model of carrageenan-induced acute pleurisy was also selected to observe the anti-inflamatory effect. The anti-inflammatory mechanism was investigated by detecting the contents of prostaglandins( PGE_2),tumor necrosis factor-alpha( TNF-α),and interleukin-1β( IL-1β) in the exudates,and the contents of TNF-α,IL-1β,and malondialdehyde( MDA) in the lung tissue were also detected.[Result]Compared with the model group,the alcohol extract of Phellodendri Chinensis Corte groups( 9. 0 and 4. 5 g/kg) had significant inhibitory effects on the acetic acid-induced permeability accentuation in the mice,while the alcohol extract of Phellodendri Chinensis Corte groups( 9. 0 and 4. 5g / kg) significantly reduced the levels of PGE_2,TNF-α and IL-1β in the exudates( P <0. 05),while the high-dose alcohol extract of Phellodendri Chinensis Corte group( 9. 0 g / kg) also reduced the contents of TNF-α,IL-1β and MDA in the lung tissue of the carrageenan treated rats( P < 0. 01),and the moderate-dose alcohol extract of Phellodendri Chinensis Corte group( 4. 5 g / kg) decreased the content of IL-1β in the lung tissue( P < 0. 01). [Conclusion]The alcohol extraction of Phellodendri Chinensis Corte possesses significant anti-inflammatory effects,which can be related to the inhibition of generation of the inflammatory mediators and its antioxidation. [Objective] To observe the anti-inflammatory effects of alcohol extract of Phellodendri Chinensis Corte and explore its mechanism. [Method] ICR mice were divided into 5 groups randomly, namely the model group, dexameathone group (0.01 g / kg) Each drug was administered to the mice orally once a day for 15 days. After 30 min of the last administration, its anti-inflammatory effect was observed by the method of acetic acid-induced permeability accentuation. SD rats were divided into 5 groups randomly, namely the model group, dexameathone group (0.01 g / kg), alcohol extraction of Phellodendri Chinensis Corte groups , 3.5 and 3.0 g / kg). Each drug was administered to the rats orally once a day for 15 days. After 30 min of the last administration, the rat model of carrageenan-induced acute pleurisy was also selected to observe the anti-inflammatory mechanism was investigated b The detection of contents of prostaglandins (PGE_2), tumor necrosis factor-alpha (TNF-α), and interleukin-1β (IL-1β) in the exudates, and the contents of TNF-α, IL-1β, and malondialdehyde ) in the lung tissue were also detected. [Result] Compared with the model group, the alcohol extract of Phellodendri Chinensis Corte groups (9.0 and 4.5 g / kg) had significant inhibitory effects on the acetic acid-induced permeability accentuation in the mice, while the alcohol extract of Phellodendri Chinensis Corte groups (9.0 and 4.5 g / kg) significantly reduced the levels of PGE_2, TNF-α and IL-1β in the exudates (P <0.05), while the high-dose alcohol extract of Phellodendri Chinensis Corte group (9.0 g / kg) also reduced the contents of TNF-α, IL-1β and MDA in the lung tissue of the carrageenan treated rats (P <0.01), and the moderate-dose alcohol extract of Phellodendri Chinensis Corte group (4.5 g / kg) decreased the content of IL-1β in the lung tissue (P <0.01). Conclusion The alcoh ol extraction of Phellodendri Chinensis Corte possesses significant anti-inflammatory effects, which can be related to the inhibition of generation of the inflammatory mediators and its antioxidation.