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目的探讨连续性血液净化治疗重度烧伤脓毒症患者的疗效及临床分析。方法 2008年7月至2012年7月期间,本院诊治的64例重度烧伤脓毒症患者,随机将其分为对照组(常规治疗)和观察组(对照组基础上,进行连续性血液净化治疗),每组各32例,对两组患者生命体征、实验室检查结果,以及白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)水平,进行观察和比较。结果与对照组相比,治疗后观察组的动脉氧分压(PaO2)明显提高,白细胞计数、血钠、尿素氮、血肌酐水平明显降低,以及IL-8和TNF-α水平显著降低,P<0.05,差异有统计学意义。结论对于重度烧伤脓毒症患者,连续性血液净化治疗能够显著改善患者的预后质量,提高临床疗效,值得临床推广。
Objective To investigate the efficacy and clinical analysis of continuous blood purification in patients with severe burn sepsis. Methods From July 2008 to July 2012, 64 patients with severe burn sepsis treated in our hospital were randomly divided into control group (conventional treatment) and observation group (on the basis of control group, continuous blood purification (32 cases in each group). The vital signs and laboratory findings of the two groups of patients and the levels of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) were observed and compared. Results Compared with the control group, PaO 2, leukocyte count, serum sodium, urea nitrogen, serum creatinine and IL-8 and TNF-α in the observation group were significantly decreased after treatment <0.05, the difference was statistically significant. Conclusion For patients with severe burn sepsis, continuous blood purification can significantly improve the prognosis of patients with quality and improve clinical efficacy, it is worth clinical promotion.