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目的探究熊去氧胆酸与羟甲烟胺治疗慢性肝内胆汁淤积的疗效及安全性。方法 100例慢性肝内胆汁淤积患者,采用随机数字表法分为A组和B组,各50例。两组患者均给予护肝、抗病毒等对症支持治疗措施,A组在此基础上加用熊去氧胆酸治疗,B组在此基础上加用羟甲烟胺治疗。对比两组患者治疗2、4周后的临床疗效、肝功能变化及不良反应发生情况。结果 A组患者治疗总有效率为80.0%,显著高于B组的62.0%,差异具有统计学意义(P<0.05);两组患者治疗前各项肝功能指标比较差异无统计学意义(P>0.05),治疗2、4周后两组患者的各项肝功能指标均较治疗前明显改善(P<0.05),治疗2周后两组患者肝功能指标比较差异无统计学意义(P>0.05),治疗4周后A组患者的肝功能指标改善情况显著优于B组,差异具有统计学意义(P<0.05);两组患者均未发现明显的药物相关不良反应。结论熊去氧胆酸在慢性肝内胆汁淤积的治疗上较羟甲烟胺更具优势,长期用药可明显提高疗效且安全性较好,值得在临床上推广和应用。
Objective To investigate the efficacy and safety of ursodeoxycholic acid and hydroxymethyl hydroxylamine in the treatment of chronic intrahepatic cholestasis. Methods One hundred patients with chronic intrahepatic cholestasis were divided into A group and B group by random number table, each 50 cases. Two groups of patients were given symptomatic treatment of liver protection, anti-virus and other measures, A group on the basis of the addition of ursodeoxycholic acid treatment, B group on the basis of treatment with hydroxylamine. The clinical efficacy, changes of liver function and adverse reactions of the two groups were compared after two and four weeks treatment. Results The total effective rate of treatment in group A was 80.0%, which was significantly higher than that in group B (62.0%, P <0.05). There was no significant difference in the indexes of liver function between the two groups before treatment (P > 0.05). After treatment for 2 and 4 weeks, the indexes of liver function in both groups were significantly improved (P <0.05), but there was no significant difference in liver function index between the two groups after 2 weeks of treatment (P> 0.05). After 4 weeks of treatment, the improvement of liver function in group A was significantly better than that in group B (P <0.05). No obvious drug-related adverse reactions were found in both groups. Conclusion Ursodeoxycholic acid has more advantages over hydroxymethylmethamine in the treatment of chronic intrahepatic cholestasis. Long-term use of ursodeoxycholic acid can obviously improve the curative effect and safety, which is worth to be popularized and applied clinically.