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目的:对比奥美拉唑、泮托拉唑、兰索拉唑及埃索美拉唑四种质子泵抑制药治疗十二指肠溃疡伴出血的疗效和安全性,并进行药物经济学研究。方法:采用回顾性分析方法,收集90例十二指肠溃疡伴出血的患者,按使用质子泵抑制药品种的不同分为奥美拉唑组、泮托拉唑组、兰索拉唑组及埃索美拉唑组等4组。比较各组疗效及安全性,并采用药物经济学方法进行评估。结果:4组的治疗总有效率比较,差异无统计学意义(P>0.05)。4组患者的平均止血时间、止血率,药品不良反应发生率比较,差异均无统计学意义(P>0.05)。采用最小成本分析法,泮托拉唑组治疗成本显著低于其他3组。结论:4组治疗方案的疗效和安全性基本相当,而泮托拉唑成本最低,是药物经济学最优方案。
OBJECTIVE: To compare the efficacy and safety of four proton pump inhibitors, including omeprazole, pantoprazole, lansoprazole and esomeprazole, for the treatment of duodenal ulcer with hemorrhage and to study the pharmacology. Methods: Ninety patients with duodenal ulcer and hemorrhage were collected by retrospective analysis. According to the different types of proton pump inhibitors, they were divided into omeprazole group, pantoprazole group, lansoprazole group and Esomeprazole group and other 4 groups. The efficacy and safety of each group were compared and evaluated by pharmacoeconomics. Results: There was no significant difference in the total effective rate between the four groups (P> 0.05). There was no significant difference in mean hemostasis time, hemostasis rate and adverse drug reaction between the 4 groups (P> 0.05). With minimal cost analysis, the cost of pantoprazole treatment was significantly lower than the other three groups. Conclusion: The efficacy and safety of the four treatment regimens are basically the same, while the lowest cost of pantoprazole is the optimal program of pharmacoeconomics.