[目的]建立ICP-MS同时测定补钙食品中Pb、Cd、Cu和As的分析方法。[方法]样品经微波消化后直接用ICP-MS进行分析。[结果]整个方法的检出限为0.002～0.015mg/kg,可以满足测定的要求,精密度优于3.3%,回收率为95.6%～105%,对2个标准参考物质的分析结果令人满意。[结论]可用ICP-MS同时测定补钙食品中Pb、Cd、Cu和As,整个方法具有简单、快速和准确的特点。 [Objective] To establish an analytical method for the simultaneous determination of Pb, Cd, Cu and As in calcium foods by ICP-MS. [Method] The samples were directly digested by microwave and analyzed by ICP-MS. [Result] The detection limit of the whole method was 0.002-0.015 mg / kg, which could meet the determination requirements. The precision was better than 3.3% and the recovery rate was 95.6% -105%. The analytical results of two standard reference materials satisfaction. [Conclusion] The method of simultaneous determination of Pb, Cd, Cu and As in calcium foods by ICP-MS is simple, rapid and accurate.