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目的评价孕三烯酮联合手术防治子宫内膜息肉的疗效。方法选150例拟行子宫内膜息肉电切术的患者,随机分为3组:术前与术后孕三烯酮组(简称术前、术后组)及对照组(n=60,60,30)。术前组口服孕三烯酮4周后入院手术;术后组术后口服孕三烯酮3个月;对照组直接入院手术,术后不服药。结果术前组的内膜较薄、内膜单位面积的腺体数目较少及间质较致密,和对照组比较有统计学意义(P<0.05);术后组的无月经率(72.2%)高于对照组(13.3%)及术前组(23.7%)。术前组及术后组的息肉复发率较低,与对照组比较有统计学意义(P<0.05)。结论孕三烯酮联合手术治疗子宫内膜息肉可提高手术成功率及降低复发率。
Objective To evaluate the efficacy of gestrinone in the prevention and treatment of endometrial polyps. Methods 150 cases of endometrial polyps resection were randomly divided into 3 groups: preoperative and post-pregnancy gestrinone group (preoperative and postoperative group) and control group (n = 60,60 , 30). The patients in the preoperative group were given oral gestrinone for 4 weeks after operation. The patients in the postoperative group were given gestrinone for 3 months after surgery. The patients in the control group were directly admitted to the hospital and were given no medication after operation. Results The preoperative group had thinner intima, fewer intima per unit area and more dense interstitium compared with the control group (P <0.05). The rate of non-menstrual flow in the postoperative group (72.2% ) Higher than the control group (13.3%) and preoperative group (23.7%). The recurrence rate of polyp in preoperative group and postoperative group was lower than that in control group (P <0.05). Conclusion Gestrinone combined with surgical treatment of endometrial polyps can improve the success rate of surgery and reduce the recurrence rate.