角蛋白（keratin）作为一组相对分子质量（M）为40000－70000不溶于水的细胞结构蛋白，在上皮细胞的发生、分化成熟过程中逐渐形成，是所有哺乳动物细胞骨架的中间丝之一，其组成因不同上皮而异。近年来，随着分子生物学技术的推广和应用，角蛋白的基础研究得到了不断深化；同 Keratin, a group of 40,000-700,000 water-insoluble cellular structure proteins with relative molecular mass (M), is gradually formed during epithelial cell differentiation and maturation and is one of the intermediate filaments of all mammalian cytoskeleton , Its composition varies with different epithelium. In recent years, with the popularization and application of molecular biology techniques, the basic research on keratin has been continuously deepened;