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目的 分析青蒿素类药物预防日本血吸虫病的效果和可能的不良反应或毒副作用。方法 纳入以高危人群为研究对象的随机对照试验 ,对纳入研究的质量进行评价 ,并进行Meta分析。结果 10个预防日本血吸虫病的随机对照试验符合纳入标准 ,均为高质量研究。其中 4个为多中心研究 ,6个为单中心研究。纳入人数范围从 318人至 5 0 98人 ,共计 12 82 9人。汇总OR 0 .11(95 %CI 0 .0 6～ 0 .2 1)表明口服青蒿素类药物的干预组的血吸虫感染率远低于对照组 ,差异有统计学意义。未发现符合本系统评价规定的毒副作用。结论 青蒿素类药物可有效预防日本血吸虫病 ;尚需更多高质量研究以比较各种服药方案之间的优劣。
Objective To analyze the effect of artemisinin on the prevention of schistosomiasis japonica and possible adverse reactions or side effects. Methods Randomized controlled trials of high-risk populations were included to evaluate the quality of the included studies and to conduct meta-analysis. Results Ten randomized controlled trials to prevent schistosomiasis japonica met the inclusion criteria and were high quality studies. Four were multicenter studies and six were single-center studies. The total number of enrolled persons ranged from 318 to 598, for a total of 12,829. The pooled OR 0.11 (95% CI 0.60 ~ 0.21) showed that the infection rate of schistosomiasis in the intervention group with oral artemisinin was much lower than that in the control group, the difference was statistically significant. No side effects were found consistent with the systematic review. Conclusions Artemisinin is effective in preventing schistosomiasis japonica; more high-quality research is needed to compare the advantages and disadvantages of various drug regimens.