目的探索适合基层医院对子痫前期早期筛查并给予早期干预,减少母儿不良结局。方法通过对1 000例符合研究标准的孕妇妊娠12周抽取血液检测血清学指标,追踪到妊娠20周完成超声多普勒对子宫动脉搏动指数的检测,血清学指标为人绒毛膜促性腺激素(h CG)、妊娠相关蛋白A(PAPP-A)、抑制素A、激活素A 4项生化指标及超声指标子宫动脉血流PI,继续追踪到终止妊娠,将队列中符合子痫前期的妊娠妇女列为观察组,其余妊娠妇女为对照组,分析其血清学指标及超声指标。结果数据采用SPSS19.0的单因素分析,5个预测指标的ROC曲线下面积比较,子宫动脉搏动指数ROC 0.974,与其他指标独立的ROC比较有统计学差异(P=0.011)。5个指标分别组合后进入Logistic回归分析,对4个指标联合及5个指标联合的预测概率进行ROC分析,后者具有明显优势(ROC曲线下面积0.992),差异有统计学意义(P<0.05)。子痫前期血清学指标联合超声指标观察组明显高于对照组,两组对比预测概率有统计学差异(P<0.05)。结论血清学指标联合超声指标对子痫前期有明确预测价值,会使预测更加准确,经济实用,推荐在基层医院适合应用并推广,对子痫前期筛查及减少母儿不良结局具备临床实用价值。 Objective To explore suitable for primary hospital screening of preeclampsia and give early intervention to reduce maternal and child adverse outcomes. Methods A total of 1000 pregnant women who met the criteria of the study were enrolled in this study. Blood samples were collected for serum biochemical tests 12 weeks after pregnancy. The pulsatility index of uterine artery was detected by ultrasound Doppler after 20 weeks gestation. The serum level of hCG CG), pregnancy-related protein A (PAPP-A), inhibin A, activin A 4 biochemical indicators and ultrasound index uterine artery blood flow PI, continue to track the termination of pregnancy, the cohort of women in line with preeclampsia For the observation group, the remaining pregnant women as a control group, analysis of their serological markers and ultrasound. Results The data were analyzed by univariate analysis of SPSS19.0. The area under the ROC curve of the five predictors was compared with the ROC 0.974 of the uterine artery pulsatile index (P = 0.011), which was independent of the other indexes. Logistic regression analysis was performed after the five indexes were combined respectively. ROC analysis was performed on the prediction probabilities of the combination of the four indicators and the combination of the five indicators. The latter had obvious advantages (area under the ROC curve was 0.992), the difference was statistically significant (P <0.05 ). The preeclampsia serological markers combined with ultrasound index observation group was significantly higher than the control group, the two groups predicted the probability of a statistically significant difference (P <0.05). Conclusion Serum indicators combined with ultrasound indicators have a clear predictive value of preeclampsia, will make the prediction more accurate, economical and practical, recommended for application and promotion in primary hospitals, screening for preeclampsia and reduce the adverse outcomes of maternal and child with clinical practical value .