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目的 研究健胃愈疡 (Jianweiyuyang ,JWYY)颗粒对溃疡的影响 ,并探讨其机制。方法 以Okabe改良法复制大鼠实验性胃溃疡 ,观察其对溃疡指数和溃疡组织学的影响 ,并用免疫组化法观察血管内皮生长因子 (VEGF)、血小板源性生长因子 (PDGF)表达的变化。结果 JWYY颗粒能提高VEGF、PDGF表达 ,明显降低溃疡指数 ,增加黏膜厚度 ,促进溃疡愈合。结论 JWYY颗粒通过提高VEGF、PDGF表达 ,提高溃疡愈合质量 ,这可能是其促进溃疡愈合的机制之一。
Objective To study the effect of Jianweiyuyang (JWYY) particles on ulcers and to explore its mechanism. Methods Okabe modified method was used to replicate experimental gastric ulcers in rats, and its effects on ulcer index and ulcer histology were observed. Changes of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) expression were observed by immunohistochemistry. . Results JWYY granules can increase the expression of VEGF and PDGF, significantly reduce the ulcer index, increase the mucosal thickness, and promote ulcer healing. Conclusion JWYY granules enhance the expression of VEGF and PDGF and improve the healing quality of ulcers, which may be one of the mechanisms that promote ulcer healing.