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目的探讨头孢米诺治疗慢性阻塞性肺疾病下呼吸道感染的临床疗效及安全性。方法将2009年8月-2010年8月,医院收治的56例慢性阻塞性肺疾病合并下呼吸道感染患者,随机分为两组,各28例;治疗组在常规治疗的基础上采用头孢米诺2 g静脉滴注,2次/d;对照组在常规治疗的基础上采用头孢他啶2 g静脉滴注,2次/d,两组疗程均为7~14 d。结果治疗组痊愈率为78.6%,有效率为92.9%,细菌清除率为93.1%;头孢他啶组痊愈率为53.6%,有效率为71.4%,细菌清除率为66.7%,两组比较差异有统计学意义。结论头孢米诺对常见的下呼吸道感染病原菌有较好的清除效果,治疗慢性阻塞性肺疾病下呼吸道感染安全、有效。
Objective To investigate the clinical efficacy and safety of cefminox in the treatment of lower respiratory tract infections in patients with chronic obstructive pulmonary disease. Methods From August 2009 to August 2010, 56 patients with chronic obstructive pulmonary disease complicated with lower respiratory tract infection were randomly divided into two groups (n = 28). The treatment group was treated with cefmenoxime 2 g intravenous infusion, 2 times / d; control group on the basis of conventional treatment with ceftazidime 2 g intravenous infusion, 2 times / d, the two courses were 7 to 14 days. Results In the treatment group, the cure rate was 78.6%, the effective rate was 92.9% and the bacterial clearance rate was 93.1%. The cure rate was 53.6% in the ceftazidime group, the effective rate was 71.4% and the bacterial clearance rate was 66.7% significance. Conclusion Cefminox has a good clearance effect on common pathogenic bacteria of lower respiratory tract infection, and is safe and effective in treating respiratory tract infections in chronic obstructive pulmonary disease.