论文部分内容阅读
采用乳化交联法制备胶原蛋白/壳聚糖/纳米SiO_2复合微球。以司班80和液体石蜡为油相,混合溶液为水相,引入硬脂酸镁(MS)作助乳化剂,以SEM、FT-IR、UV、激光粒度仪为表征手段研究了油水体积比、搅拌速率、交联剂与混合溶液体积比和纳米SiO_2对复合微球的成球性及其载药释药性能的影响。结果表明,MS的助乳化效果较好,在纳米SiO_2和混合溶液质量比为2%(wt,质量分数)时,盐酸小檗碱载药微球的载药率为15.66%,包封率为66.52%,维生素D载药微球的载药率为3.08%,包封率为48.54%。结论:制备了粒度分布集中的药物缓释微球,纳米SiO_2使微球具有更好的缓释性能,且在pH较低时不易分解,减少粘附。
Preparation of collagen / chitosan / nano-SiO_2 composite microspheres by emulsion cross-linking method. In this experiment, the ratio of oil to water was determined by using SEM, FT-IR, UV and laser particle sizer as the oil phase of spar 80 and liquid paraffin with the mixed solution as the water phase and magnesium stearate (MS) as emulsifier. , The stirring rate, the volume ratio of cross-linking agent and mixed solution and the effect of nano-SiO 2 on the properties of the composite microspheres. The results showed that the emulsifying effect of MS was better. The drug-loading rate of berberine hydrochloride microspheres was 15.66% when the mass ratio of nano-SiO 2 and mixed solution was 2% (wt, mass fraction) 66.52%, vitamin D drug-loaded microspheres drug loading rate was 3.08%, encapsulation efficiency was 48.54%. CONCLUSIONS: The drug-loaded microspheres with a large particle size distribution were prepared. The nano-SiO 2 prepared the microspheres with better sustained-release properties and did not decompose at low pH and decreased the adhesion.