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目的观察药物去势加雄激素阻断剂—缓退瘤(Flutamide)之全雄激素阻断疗法治疗转移性前列腺癌疗效。方法回顾性分析14例药物去势加缓退瘤治疗转移性前列腺癌的临床资料。结果所有病人在用促黄体生成素释放激素(LHRH)类似物一个月后血睾酮均降至去势水平。12例有治疗效果。3例出现肝功能异常,5例出现食欲减退,14例出现性欲减退和阳痿,2例出现血象异常,5例出现潮热、盗汗。结论药物去势加雄激素阻断剂之全雄激素阻断疗法,治疗初发的转移性前列腺癌疗效肯定,去势稳定。
Objective To observe the curative effect of whole androgen blockade therapy of castration and androgen and blocker - Flutamide in the treatment of metastatic prostate cancer. Methods A retrospective analysis of 14 cases of castration and withdrawal of tumor treatment of metastatic prostate cancer clinical data. Results In all patients, serum testosterone dropped to the castrated level after one month with luteinizing hormone releasing hormone (LHRH) analogs. 12 cases have a therapeutic effect. 3 cases had abnormal liver function, 5 cases showed loss of appetite, 14 cases of loss of libido and impotence, 2 cases of blood abnormalities, 5 cases of hot flashes, night sweats. Conclusion The all-androgen-blocking therapy of castration and androgen blockade is effective in the treatment of newly diagnosed metastatic prostate cancer and stable in castration.