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目的 探讨伴高血压的 Ig A肾病患者流行病学及临床病理特点。方法 5 40例 Ig A肾病分为高血压组(HP组 ,2 14例 )与非高血压组 (N- HP组 ,32 6例 )。对比分析两组流行病学及临床病理资料。结果 伴高血压的 Ig A肾病患者以男性多见、男∶女为 2 .6 3∶ 1,临床表现以蛋白尿伴血尿为主 ,其次为单纯蛋白尿 ,而呈肾病综合征伴或不伴血尿者及单纯血尿者较少见。与 N- PH组相比 ,其尿蛋白排泄量较多 ,血浆白蛋白水平较低 ,胆固醇、甘油三酯及血肌酐水平较高 ,肾小球硬化率、系膜增生程度、肾小管间质病变及肾小动脉病变程度均较重 ,血肌酐升高发生率也明显较高。结论 伴高血压的 Ig A肾病以中青年男性多见 ,临床表现以蛋白尿伴血尿为主 ,肾脏病变较重 ,预后差
Objective To investigate the epidemiological and clinicopathological features of IgA nephropathy patients with hypertension. Method 5 40 cases of IgA nephropathy were divided into hypertensive group (HP group, 214 cases) and non-hypertensive group (N HP group, 32 6 cases). Comparative analysis of two groups of epidemiological and clinical pathological data. Results The patients with IgA nephropathy with hypertension were more common in males, with a male-female ratio of 2.6: 3: 1. The main clinical manifestations were proteinuria with hematuria, followed by simple proteinuria, with or without nephrotic syndrome Hematuria and hematuria are rare. Compared with N-PH group, urinary protein excretion was higher, plasma albumin level was lower, cholesterol, triglyceride and serum creatinine were higher, glomerular sclerosis, mesangial proliferation, tubulointerstitial Lesions and renal artery lesions were severe, elevated serum creatinine was also significantly higher. Conclusions IgA nephropathy with hypertension is more common in middle-aged and young men. The clinical manifestations are mainly proteinuria with hematuria, severe kidney disease and poor prognosis