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目的:分析阿卡波糖致患者肝损害的特点,为临床安全用药提供参考。方法:利用国内外医药数据库,检索以阿卡波糖、拜糖平、肝损害、肝毒性、肝炎、转氨酶升高值和acarbose,liver injury,hepatotoxicity和hepatitis等为关键词,下载相关病例报告,分析病例资料和用药情况。结果:共检索到阿卡波糖致患者肝损害不良反应病例20例,其致肝损害特点为(1)40岁以上中老年女性患者的比例大于男性患者;(2)肝损害似乎与用药剂量无关;(3)联合用药者占比较高;(4)肝损害出现的时间较晚(中位时间2月);(5)症状以全身乏力、胃肠不适、恶心、呕吐、黄疸、黄色或茶色尿、腹痛等为临床表现为主;(6)实验室检查示ALT、AST、胆红素、ALP升高;(7)肝损害分型均为肝细胞型。结论:临床医务人员特别是糖尿病专科医师应关注阿卡波糖的肝损害不良反应的发生。
Objective: To analyze the characteristics of acarbose-induced liver damage in patients with clinical safety medication to provide a reference. Methods: Using the domestic and foreign medical databases, we searched the relevant key case reports with key words acarbose, albuterol, liver damage, hepatotoxicity, hepatitis, elevated transaminases and acarbose, liver injury, hepatotoxicity and hepatitis, Analysis of case information and medication. Results: A total of 20 cases of adverse reactions of liver damage induced by acarbose were found. The liver damage was characterized by (1) the proportion of middle-aged and elderly women over 40 years old was higher than that of male patients; (2) (4) liver damage occurred late (median time in February); (5) the symptoms of generalized weakness, gastrointestinal discomfort, nausea, vomiting, jaundice, yellow or Brown urine, abdominal pain and other clinical manifestations as the main; (6) laboratory tests showed ALT, AST, bilirubin, ALP increased; (7) liver damage type are hepatocellular type. Conclusion: Clinical medical staff, especially diabetologists should pay attention to the occurrence of acarbose liver damage adverse reactions.