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目的探讨尿微量白蛋白(mAlb)、转铁蛋白(UTf)、β2微球蛋白(β2-MG)和N-乙酰-β-D氨基葡萄糖苷酶(NAG)联合检测对2型糖尿病(DM)患者肾损伤早期诊断的价值。方法采用免疫透射比浊法和比色法检测62例2型糖尿病患者及40例健康体检者晨尿尿微量白蛋白(mAlb)、转铁蛋白(UTf)、β2微球蛋白(β2-MG)和N-乙酰-β-D氨基葡萄糖苷酶(NAG)含量。结果2型糖尿病患者mAlb、UTf、β2-MG、NAG水平均显著高于对照组,差异有统计学意义(P<0.01)。结论联合检测糖尿病患者尿液4项指标.可以早期对其常见并发症之一的糖尿病肾损伤作出诊断。为临床提供早期的诊断依据,阻止或延缓糖尿病发展至肾损伤,对于2型糖尿病患者早期肾损伤诊断有一定的临床意义。
Objective To investigate the effects of combined use of mAlb, UTf, β2-MG and NAG on type 2 diabetes mellitus (DM) The value of early diagnosis of renal injury in patients. Methods Urine microalbumin (mAlb), transferrin (UTf), β2 microglobulin (β2-MG) in morning urine of 62 patients with type 2 diabetes mellitus and 40 healthy subjects were detected by immunoturbidimetry and colorimetric assay. And N-acetyl-β-D glucosaminidase (NAG) content. Results The levels of mAlb, UTf, β2-MG and NAG in type 2 diabetic patients were significantly higher than those in control group (P <0.01). Conclusions Combined detection of 4 indicators of urine in patients with diabetes can be early diagnosis of diabetic renal injury, one of the common complications. To provide an early diagnosis of clinical basis to prevent or delay the development of diabetes to renal injury, for the diagnosis of type 2 diabetes early renal injury has some clinical significance.