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目的分析男性不育症患者精液解脲支原体(UU)和抗精子抗体(AsAb)对精液参数的影响,并探讨精液AsAb和UU感染的关系。方法收集男性不育症患者303例,采用计算机辅助分析系统行精液常规分析,用UU分离鉴定培养液检测精液UU,采用混合抗球蛋白反应试验(mixed antiglobulin reaction,MAR)检测精液AsAb。结果UU和AsAb阳性组精子活力均较UU和AsAb阴性组下降,而两组之间精子密度无显著差异。AsAb阳性组中UU阳性率显著高于AsAb阴性组。UU阳性组经敏感抗生素治疗后精子活力显著改善,AsAb阳性率显著下降。结论UU和AsAb对精子运动主要参数有明显影响,是导致男性不育的重要因素,而UU是产生AsAb的重要原因之一。
Objective To analyze the influence of semen UU and AsAb on semen parameters in male infertility patients and to explore the relationship between semen AsAb and UU infection. Methods 303 cases of male infertility were collected, routine sperm routine analysis was performed by computer-aided analysis system, UU was used to detect semen UU, and mixed serum anti-globulin (AsAb) was detected by mixed antiglobulin reaction (MAR). Results The sperm motility of UU and AsAb positive groups were lower than that of UU and AsAb negative groups, but there was no significant difference in sperm density between the two groups. The positive rate of UU in AsAb positive group was significantly higher than that in AsAb negative group. UU positive group after treatment with sensitive antibiotics significantly improved sperm motility, AsAb positive rate decreased significantly. Conclusions UU and AsAb have significant influence on the main parameters of sperm motility, which is an important factor leading to male infertility. UU is one of the important reasons for AsAb production.