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目的考察补肾助孕方对黄体功能不全性(LPD)不孕症大鼠卵巢组织中血管内皮生长因子(VEGF)蛋白表达的影响。方法采用Western-Blot检测补肾助孕方高、中、低剂量组与阳性药、空白对照、模型组大鼠卵巢组织中VEGF蛋白表达。结果补肾助孕方各剂量组、阳性药组、空白组与模型组比较,VEGF蛋白表达的条带明显加深。结论补肾助孕方增加LPD大鼠卵巢组织中VEGF蛋白表达,从而促进黄体毛细血管生成,确保黄体最佳发育,起到治疗黄体功能不全性不孕症的作用。
Objective To investigate the effect of Bushen Zhuyun Prescription on the expression of vascular endothelial growth factor (VEGF) protein in the ovary of infertility rats with luteal incompetence (LPD). Methods Western-blot was used to detect the expression of VEGF protein in the ovary tissues of high-, middle-, and low-dose group and positive drug, blank control and model group. Results Compared with the model group, the bands of VEGF protein expression were significantly deepened in each dose group, positive drug group and blank group of Bushen Zhuyun Prescription. Conclusion Bushen Zhuyun Recipe increases the expression of VEGF protein in ovarian tissues of LPD rats, which promotes corpus luteum capillary angiogenesis and ensures optimal development of the corpus luteum, which plays a role in the treatment of luteal insufficiency infertility.