论文部分内容阅读
血栓症(如急性心肌梗塞(AMI)、静脉血栓塞等)是一类严重危及人类健康及生命的心血管疾病。世界卫生组织统计,到目前,心血管发病及死亡率已经跃居第一位(黄,2003)。世界每年心血管病死亡人数约1300万,仅美国急性心肌梗死人数即为150万,约1/3致命,占美国疾病总死亡率的30%。据卫生部统计,我国心脏病和脑中风死亡率也很高(赵和何,2003)。所以近年来,研究有效的治疗心血管疾病的药物及方法引起了人们越来越多的关注。以凝血酶为靶点,用凝血酶抑制剂来抑制血栓的生成的抗栓疗法即是临床治疗血栓的方法之一。
Thrombosis (such as acute myocardial infarction (AMI), venous thrombosis, etc.) is a group of serious cardiovascular diseases that endanger human health and life. According to the statistics of the World Health Organization, up to now, cardiovascular morbidity and mortality have risen to No. 1 (Huang 2003). The world cardiovascular disease death toll about 13 million, only the United States the number of acute myocardial infarction is 1.5 million, about 1/3 fatal, accounting for 30% of the total disease mortality in the United States. According to the statistics of the Ministry of Health, the death rate of heart disease and stroke in China is also high (Zhao and Ho 2003). Therefore, in recent years, more and more attention has been paid to the study of effective drugs and methods for treating cardiovascular diseases. Antithrombotic therapy, which uses thrombin inhibitors as a target of thrombin inhibition, is one of the methods for clinical treatment of thrombus.