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目的:探讨体外受精-胚胎移植(IVF-ET)妊娠结局的影响因素。方法:对175例不孕患者(177个IVF-ET周期)的临床资料进行回顾性分析,采用多因素非条件逐步Logistic回归方法分析女方年龄、不孕类别、基础卵泡刺激素(FSH)水平、促性腺激素(Gn)用量、人绒毛膜促性腺激素(HCG)注射日子宫内膜厚度、HCG注射日血清雌二醇(E2)水平和获卵数与IVF-ET妊娠结局的关系。结果:年龄≥35岁(OR=0.699 2)、基础FSH≥15IU/L(OR=0.872 4)、HCG注射日血清E2≥2 997 pg/ml(OR=0.823 1)是妊娠率降低的因素(P均<0.05),HCG注射日子宫内膜厚度≥10 mm(OR=1.377 1)和获卵数增加(OR=1.045 0)是妊娠率提高的因素(P均<0.05)。结论:IVF-ET妊娠结局受女性年龄、基础FSH水平、Gn用量、HCG注射日子宫内膜厚度、HCG注射日血清E2水平和获卵数多因素的影响。
Objective: To investigate the influencing factors of pregnancy outcome in IVF-ET (IVF-ET). Methods: The clinical data of 175 cases of infertility (177 IVF-ET cycles) were retrospectively analyzed. The age, infertility category, basic follicle stimulating hormone (FSH) level were analyzed by multivariate stepwise Logistic regression. The amount of gonadotropin (Gn), the thickness of endometrium on the day of human chorionic gonadotropin (HCG) injection, the level of serum estradiol (E2) on the day of HCG injection and the relationship between the number of oocytes and the pregnancy outcome of IVF-ET. Results: Serum E2≥2997 pg / ml (OR = 0.823 1) of ≥35 years old (OR = 0.699 2), basal FSH ≥15 IU / L (OR = 0.872 4) P <0.05). The increase of pregnancy rate after endometrial thickness≥10 mm (OR = 1.377 1) and the number of oocytes retrieved on the day of HCG injection (OR = 1.045 0) were all significant (all P <0.05). Conclusion: The pregnancy outcome of IVF-ET is influenced by the age of the female, the basal level of FSH, the amount of Gn, the thickness of endometrium on the day of HCG injection, the serum level of E2 on the day of HCG injection and the number of oocytes retrieved.