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洋地黄的临床应用历史悠久。近20多年来证明洋地黄的正性肌力效应与剂量呈线性关系,即少量洋地黄就能增强心肌收缩。用较小的但在剂量——效应曲线上较为安全的那部分剂量维持,即能达到洋地黄化的治疗浓度,并能明显减少中毒发生率。相反,当接近最大效应时,再提高药物的组织浓度只能收到根小的效益。对于充血性心力衰竭病人,如何改善他们的心功能,提高生活质量,这是很重要的问题。现
Digitalis has a long history of clinical application. Over the past 20 years to prove digitalis positive inotropic effect and dose was linear, that is, a small amount of digitalis can enhance myocardial contractility. Maintaining the concentration of digitalis, with a smaller but safe dose on the dose-response curve, significantly reduces the incidence of poisoning. Conversely, when the maximum effect is approached, increasing the tissue concentration of the drug only receives little benefit. For congestive heart failure patients, how to improve their heart function and improve the quality of life, which is a very important issue. Now