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目的:分析原发性肝癌(primary hepatic carcinoma,PHC)患者血清P53抗体与临床特征的关系.方法:用ELISA法定量分析68例肝癌患者首诊时血清P53抗体,并用单因素和多因素统计方法分析与性别、年龄、饮酒史、HbsAg、KPS评分、病理诊断、肿瘤分化程度、肝硬化、肿瘤生长方式、肿瘤分期、血管侵犯、有无肝外转移、Child分级、血清白蛋白、AFP、血清铁蛋白等的相关性.结果:68例PHC血清P53抗体阳性率29.4%(20/68).单因素分析显示,血清P53抗体阳性与肿瘤分化程度低(P=0.020)、肝外转移(P=0.002)、肿瘤分期晚(P=0.027)、血管侵犯有关(P=0.010).多因素分析显示只有肝外转移与P53抗体阳性有关(OR=4.185,P=0.022).结论:血清P53抗体阳性与PHC的不良生物学特征有关.
PURPOSE: To analyze the relationship between serum P53 antibody and clinical features in patients with primary hepatic carcinoma (PHC) .Methods: The serum levels of P53 antibody in serum of 68 patients with primary hepatocellular carcinoma (HCC) diagnosed by first-hand quantitative ELISA were analyzed by ELISA and analyzed by univariate and multivariate statistical methods Analyzes were compared with gender, age, drinking history, HbsAg, KPS score, pathological diagnosis, tumor differentiation, cirrhosis, tumor growth, tumor staging, vascular invasion, with or without extrahepatic metastasis, Child classification, serum albumin, AFP, serum (P <0.05) .Conclusion: The positive rate of P53 antibody in 68 patients with PHC was 29.4% (20/68). The univariate analysis showed that the positive rate of serum P53 antibody was lower than that of tumor (P = 0.020) (P = 0.027) and vascular invasion (P = 0.010) .Multivariate analysis showed that only extrahepatic metastasis was associated with positive P53 antibody (OR = 4.185, P = 0.022) .Conclusion: Serum P53 antibody Positive and negative PHC biological characteristics.