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过敏性紫癜肾炎(HSPN)和IgA肾病(IgAN)的病因尚不明确。近年来随着分子生物学等研究手段的成熟和深入,一些研究成果显示某些基因如血管紧张素I转换酶基因、白细胞介素-受体拮抗剂基因、白细胞介素-1基因、肿瘤坏死因子基因、内皮一氧化氮合酶基因、补体C4基因、人类白细胞抗原基因、子宫球蛋白基因等的多态性与HSPN和IgAN的易感性、病理进展、治疗及预后明显相关。本文就近年来与HSPN和IgAN有关的基因多态性的研究进展作一综述。
The etiology of Henoch-Schonlein purpura nephritis (HSPN) and IgA nephropathy (IgAN) is not yet known. In recent years, with the development of molecular biology and other research methods, some studies have shown that certain genes such as angiotensin I converting enzyme gene, interleukin-receptor antagonist gene, interleukin-1 gene, tumor necrosis The polymorphisms of factor gene, endothelial nitric oxide synthase gene, complement C4 gene, human leukocyte antigen gene and uteroglobin gene are significantly associated with the susceptibility to HSPN and IgAN, pathological progress, treatment and prognosis. This review summarizes recent advances in the study of HSPN and IgAN related gene polymorphisms.