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目的评价本地区短程化疗方案治疗新发涂阳肺结核患者的临床疗效,分析耐药原因,减少耐药产生,提高一次性治愈率。方法回顾性分析92例经临床初次确诊并给予短程化疗的肺结核患者的临床及辅助检查资料。对符合条件者分别于1、2、6月末对其痰进行检测并培养,对临床显效、显效不明显或无效者进行分析。结果化疗1、2、6月末痰检转阴率分别为84.78%、94.57%、94.57%;临床治疗有效率分别为91.3%、97.83%、100.00%;治疗结束92例中,规律服药81例中有1例痰检未转阴,占1.23%,11例未规律服药者4例痰检未转阴,占36.36%。结论短程化疗方案在本地区对新发涂阳肺结核仍有很好疗效,但化疗期间间断、中断或不规律服药是产生耐药导致疗效不佳的主要原因。
Objective To evaluate the clinical efficacy of short-course chemotherapy in this area in the treatment of newly-developed smear-positive pulmonary tuberculosis patients, analyze the causes of drug resistance, reduce the generation of drug resistance and improve the one-time cure rate. Methods A retrospective analysis of 92 cases of clinically diagnosed and given short-course chemotherapy in patients with pulmonary tuberculosis clinical and auxiliary examination data. Those who meet the criteria at the end of 1, 2, 6, respectively, the sputum were detected and cultured, the clinical significant, markedly effective or ineffective were analyzed. Results The negative rates of sputum examination at the end of 1, 2 and 6 months of chemotherapy were 84.78%, 94.57% and 94.57% respectively. The effective rates of clinical treatment were 91.3%, 97.83% and 100.00% respectively. Among the 92 cases There was 1 case of sputum not negative, accounting for 1.23%, 11 cases of unscheduled medication 4 cases of sputum did not turn negative, accounting for 36.36%. Conclusions The short-course chemotherapy regimen still has a good effect on newly-developed smear-positive pulmonary tuberculosis in the region. However, intermittent, intermittent or irregular medication during chemotherapy is the main reason leading to poor curative effect.