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目的:探讨了慢性丙型肝炎患者血清脯氨酸肽酶活性与IGF-I、SS水平检测的临床意义。方法:应用生化法和化学发光法对30例慢性丙型肝炎患者进行了脯氨酸肽酶与IGF-I、SS含量测定。并与35名正常人作比较。结果:慢性丙型肝炎患者血清脯氨酸肽酶、IGF-I和SS水平均非常显著地高于正常人组(P<0.01),且血清脯氨酸肽酶活性水平与IGF-I、SS水平呈显著正相关(r=0.6133、0.5782、p<0.01)。结论:检测慢性丙型肝炎患者血清脯氨酸肽酶活性和IGF-、SS水平的变化有助于了解本病的发生机制和预后评估。“,”Objective to explore the Clinical significance of changes of measurement of serum PLD、IGF-I and SS levels in patients with chronic hepatitis C. Methots Serum PLD(with Biochemistry) Serum IGF-I、SS(with RIA) levels were determined in 30 patients with chronic hepatitis C and 35 Controls. Results serccm PLD IGF-I and SS leveles in the patients with chronic hepatitis wre significantly higher than those in controls(p<0.01), Serum PLD levels were positively correlated with serum IGF-I and SS levels (r=0.6133、0.5782、p<0.01). Conclusions Detection of Serum PLD,IGF-I and SS levels of Correlation were helpful outcome predictim in pationts with chronic hepatitis C.