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目的:观察单纯疱疹病毒性脑炎临床特点,探讨无环鸟苷的临床疗效。方法:将51例HSE患儿随机分为治疗组24例和对照组27例。治疗组用无环鸟苷5～10mg/kg·d,疗程10～14d,对照组用三氮唑核苷10～15mg/kg·d,疗程10～14天,观察治疗后体温正常天数,意识清醒、肢瘫恢复、头痛呕吐消失、心电图好转天数,平均住院天数及好转率、死亡率等临床指标。结果:治疗组除心电图好转天数与对照组比较无显著性差异外,其余临床指标均有显著性差异。结论:无环鸟苷早期及时治疗HSE,临床症状改善显著,预后良好。
Objective: To observe the clinical features of herpes simplex encephalitis and to investigate the clinical efficacy of acyclovir. Methods: 51 children with HSE were randomly divided into treatment group (24 cases) and control group (27 cases). Treatment group with acyclovir 5 ~ 10mg / kg · d, treatment of 10 ~ 14d, the control group with ribavirin 10 ~ 15mg / kg · d, treatment of 10 to 14 days, observe the normal body temperature after treatment, awareness Sober, recovery of limb paralysis, disappearance of headache and vomiting, electrocardiogram improvement days, average days of hospitalization and improvement rate, mortality and other clinical indicators. Results: In addition to the treatment group, the number of days electrocardiogram improvement compared with the control group no significant difference, the remaining clinical indicators were significantly different. Conclusion: Acycline guanosine treatment of HSE early, the clinical symptoms improved significantly, the prognosis is good.