,PML-RARA mutations confer varying arsenic trioxide resistance

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Dear Editor,Acute promyelocytic leukemia (APL) caused by the malignant proliferation of bone marrow-derived cells,which is driven by the chromosomal translocation,leading to the fusion of the promyelocytic leukemia gene (PML) and the retinoic acid receptor-a gene (RARA) (de The et al.,1990;Goto et al.,2011).
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