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目的:观察薏苡仁对短暂性脑缺血发作(TIA)血浆溶血磷脂酸(LPA)水平影响。方法:将64例TIA高危组患者分为薏苡仁1组和阿司匹林1组,将78例TIA低危组患者分为薏苡仁2组和阿司匹林2组,测定各组治疗30 d前后血浆LPA值。结果:薏苡仁1组血浆LPA值(6.49±1.87)μmol·L~(-1),薏苡仁2组血浆LPA值(4.55±1.45)μmol·L~(-1);阿司匹林1组血浆LPA值(6.49±1.87)μmol·L~(-1),阿司匹林2组血浆LPA值(4.55±1.45)μmol·L~(-1),两者比较差异有统计学意义(P<0.05)。结论:薏苡仁可降低TIA血浆LPA水平,是脑中风预防性治疗的有效中药。
Objective: To observe the effect of Yiyiren on plasma lysophosphatidic acid (LPA) level in patients with transient ischemic attack (TIA). Methods: Sixty-four patients with high-risk TIA were divided into two groups: Coix Cohort 1 and aspirin group 1, and 78 low TIA patients were divided into two groups: Coix Cohort 2 and aspirin 2 groups. Results: Plasma LPA (6.49 ± 1.87) μmol·L -1 in Coixenolone group 1 and LPA (4.55 ± 1.45) μmol·L -1 in Coix group 2 were significantly lower than those in Coix group (6.49 ± 1.87) μmol·L -1. The plasma LPA level of Aspirin group 2 was (4.55 ± 1.45) μmol·L -1, the difference was statistically significant (P <0.05). Conclusion: Coix seed can reduce LPA level in TIA plasma and is an effective traditional Chinese medicine for prophylactic treatment of stroke.